Urolithin A

What is Urolithin A?

Urolithin A is a metabolite produced by the gut microbiota from ellagitannins, a type of polyphenol found in certain foods like pomegranates, berries, and nuts. It has gained attention for its potential health benefits, particularly in the context of aging, muscle function, and mitochondrial health.

Key Benefits and Uses of Urolithin A

Mitochondrial Health: Urolithin A is known for its potential to improve mitochondrial function by inducing a process called mitophagy, which removes damaged mitochondria from cells and enhances the regeneration of healthy ones. This effect is associated with improved muscle function, particularly in aging individuals.

Anti-Aging Properties: Urolithin A has been studied for its anti-aging effects due to its impact on mitochondrial health. It has shown a potential to improve muscle endurance, reduce muscle fatigue, and enhance overall cellular health, which may contribute to a healthier aging process.

Anti-Inflammatory and Antioxidant Effects: Urolithin A also exhibits antioxidant and anti-inflammatory properties. It can help neutralize free radicals and reduce oxidative stress linked to various chronic conditions like cardiovascular disease, neurodegenerative diseases, and metabolic disorders.

Potential for Neuroprotection: Research suggests that Urolithin A may also have neuroprotective properties, potentially helping to protect brain cells from degeneration and improve cognitive function.

The Research of Urolithin A

Urolithin A is currently investigated for its potential health benefits, particularly in aging, muscle health, and cognitive function. It is already available as a dietary supplement in some markets, branded under different names, such as Mitopure.

Urolithin A Manufacturing Process

The manufacturing process of Urolithin A involves several key steps, starting from simpler precursor molecules and using various organic reactions to construct the final compound.

Starting Materials:

The synthesis of Urolithin A typically begins with simpler aromatic compounds like 2,4,7-trihydroxy-9H-fluoren-9-one or other related fluorenone derivatives. These molecules serve as the core structure, and additional functional groups are introduced to construct the desired molecule.

Oxidative Coupling:

Formation of Fluorenone Skeleton: The core fluorenone structure is often synthesized via an oxidative coupling reaction. This step involves the formation of the fluorenone framework by connecting aromatic rings through a suitable oxidizing agent.

Hydroxylation:

Introduction of Hydroxyl Groups: Once the fluorenone skeleton is obtained, the next step involves introducing hydroxyl groups (-OH) at the appropriate positions. This is achieved using hydroxylating agents or through selective oxidation processes.

Demethylation :

Removal of Protecting Groups: If the hydroxyl groups were initially protected (e.g., as methoxy groups) during earlier stages of the synthesis, they would be demethylated using demethylation agents like boron tribromide (BBr₃) or other similar reagents to yield free phenolic groups.

Cyclization:

Formation of the Urolithin A Structure: The synthesized molecule may undergo cyclization reactions, where parts of the molecule form a new ring structure to match the desired three-ring configuration of Urolithin A.

Purification and Crystallization:

Purification: The synthesized Urolithin A is purified using techniques like recrystallization or column chromatography to remove impurities or byproducts from the reaction.

Final Quality Check:

Characterization: The final product is characterized and verified using spectroscopic methods like Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), and Infrared (IR) Spectroscopy to confirm the correct structure and purity.

Where to buy Urolithin A bulk powder?

Nutraflux is known for offering high-quality nutraceutical ingredients, including Urolithin A. We provide bulk powder options and are considered a reliable choice due to their focus on purity, quality, and customer service.Belows are our advantages:

• Purity and Quality: Always ensure that the supplier provides a Certificate of Analysis (CoA) to verify the purity and potency of the product.
• Regulatory Compliance: Check if the supplier complies with relevant regulatory standards, such as Good Manufacturing Practices (GMP) and other international guidelines.
• Pricing and Bulk Discounts: Compare prices from different suppliers and inquire about discounts for bulk purchases.