Lithium Orotate
| Product Name | Lithium Orotate powder |
| Other Name | LiOr, LiC5H3N2O4·H2O,C5H3LiN2O4 |
| CAS Number | 5266-20-6 |
| Molecular Formula | C5H3LiN2O4H2O |
| Molecular Weight | 162.03 |
| Specifications | 98%-102% |
| Appearance/color | White to off-white powder |
| Application | Dietary supplement |
| Bulk Package | 25kg/drum |
| OEM services | Available upon specific requirement |
OEM MOQ: 500 Units
Place of Origin: China
Bulk Package: 25kg/drum
Port: Shanghai, China
Payment terms: T/T, Letter of Credit, Western Union
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What is Lithium Orotate?
Lithium is beneficial for mood stabilization, anxiety reduction, and cognitive enhancement.
Lithium orotate is a compound consisting of lithium, an alkali metal, and orotic acid, a natural substance involved in the body’s production of nucleic acids.
Some proponents suggest that lithium orotate more readily crosses the blood-brain barrier compared to other lithium salts to improve our mental health.
Lithium Orotate Benefits
1. Mood Stabilization
It is believed to help stabilize mood, particularly for individuals with mood disorders such as bipolar disorder or depression. It’s thought to have similar effects to prescription lithium carbonate but at much lower doses.
2. Neuroprotective Effects
Some research suggests that lithium, in general, may have neuroprotective properties, potentially helping to protect brain cells from damage and supporting brain health. This is often cited as a reason for its use in preventing neurodegenerative diseases like Alzheimer’s.
3. Cognitive Enhancement
Lithium orotate may have cognitive benefits, including improved memory, focus, and learning abilities. These effects are usually attributed to lithium’s role in supporting neurotransmitter function and promoting brain health.
4. Anxiety Reduction
It is sometimes used as a natural treatment for anxiety due to its calming effects on the nervous system. Users report feeling more relaxed and less prone to stress when taking low doses of lithium orotate.
5. Improved Sleep
Some people take lithium orotate to help with sleep issues, mainly if these issues are related to mood disorders or stress.
Mechanism Of Action
Lithium orotate inhibits enzymes such as glycogen synthase kinase-3 (GSK-3) and inositol monophosphatase.
GSK-3 inhibition is significant, as this enzyme plays a role in neuroplasticity and cellular signaling.
By inhibiting GSK-3, lithium may promote neurogenesis and synaptic plasticity.
Lithium Orotate Uses
LiC5H3N2O4·H2O is typically taken as an oral dietary supplement.
It is most commonly available in tablet or capsule form.
The dosage on the label typically refers to the amount of lithium orotate, but it’s important to note how much elemental lithium (the active component) is present.
For example, a 120 mg tablet may contain about 5 mg of elemental lithium.
Manufacturing Process
Dissolving orotic acid and lithium hydroxide in water. Stirring the solution, allowing the lithium hydroxide to react with the orotic acid to form lithium orotate. The reaction mixture is then filtered to remove impurities. The resulting lithium orotate solution is evaporated to remove water, leaving behind lithium orotate crystals. These crystals are dried and milled into a fine powder.
Lithium Orotate vs. Lithium
When we talk about lithium, we usually mean lithium carbonate or lithium citrate.
Lithium orotate and lithium carbonate are both forms of lithium but differ in composition, use, dosing, and regulatory status. Here’s a detailed comparison:
| Composition | Usage | Dosage | |
| Lithium Orotate | A compound of lithium and orotic acid. Orotic acid acts as a carrier for lithium ions.
|
Marketed as a dietary supplement, primarily used for mild mood support, cognitive enhancement, and stress management. It is not FDA-approved for any medical condition.
|
Typically used in much lower doses (5 to 20 mg of elemental lithium per day). The lower doses are intended to avoid side effects seen with higher doses of prescription lithium.
|
| Lithium Carbonate/lithium citrate | A salt consisting of lithium and carbonate. It is one of the most commonly prescribed forms of lithium for medical use.
|
A prescription medication used to treat bipolar disorder and occasionally for major depressive disorder. It is FDA-approved and well-established for managing mood disorders. | Prescribed in higher doses, ranging from 600 to 1800 mg per day, to achieve therapeutic levels for mood stabilization. Dosing is based on blood levels and clinical response. |
| Technical Data Sheet | ||
| Product and Batch Information | ||
| Product Name: | Lithium Orotate | |
| CAS NO. | 5266-20-6 | |
| Molecular Formular: | C5H3LiN2O4H2O | |
| Molecular Weight: | 162.03 | |
| Country of Origin: | P.R. China | |
| Item | Specification | Test Method |
| Active Ingredients | ||
| Assay(%,based on dried ) | 98%-102% | ICP-AES |
| Lithium ion | 3.7%-4.3% | ICP-AES |
| Physical Control | ||
| Appearance | Fine Powder | Visual |
| Color | White to off-white | Visual |
| Odor | Odorless | Organoleptic |
| Taste | Characteristic | Organoleptic |
| Partical Size | 95% pass 60 mesh | Cph |
| Loss on drying | ≤5.0% | Cph |
| Chemical Control | ||
| Heavy metals | NMT 20ppm | Atomic Absorption |
| Sulfate(SO4) % | ≤0.1% | Atomic Absorption |
| Microbiological Control | ||
| Total Plate Count | 1000cfu/g Max | AOAC |
| Yeast & Mold | 100cfu/g Max | AOAC |
| E.Coli | Negative | AOAC |
| Salmonella sp. | Negative | AOAC |
| P. aeruginosa | Negative | AOAC |
| S. Aureus | Negative | AOAC |
| Packing and Storage | ||
| Packing | Pack in paper-drums and two plastic-bags inside. 25Kg per Drum | |
| Storage | Store in a well-closed container away from moisture and direct sunlight. Storage temperature Room Temperature 25℃ | |
| Shelf Life | 2 years if sealed and stored properly. | |
