Fisetin Powder

What is Fisetin Powder?

Fisetin is a natural flavonoid compound widely found in fruits and vegetables such as strawberries, apples, and grapes. Its primary functions include antioxidant, anti-inflammatory, and senolytic activities. These effects have been validated in yeast, fruit flies, nematodes, and mice, demonstrating their potential anti-aging and lifespan-extending properties.

How does Fisetin work?

Firstly, it can selectively eliminate senescent cells by inhibiting their pro-survival pathways, such as BCL-2, thereby reducing their negative impact on surrounding healthy tissues.

Secondly, fisetin can activate longevity-related pathways such as AMPK and SIRT1, enhancing cellular energy metabolism and repair capacity.

In addition, it can suppress the activity of NF-κB, reducing the release of pro-inflammatory factors and thereby lowering chronic inflammation levels.

These multi-targeted mechanisms give fisetin unique advantages in anti-aging and disease prevention.

Fisetin Powder Manufacturing Process

According to the above flow chart, let us see how to get high-quality fisetin:

Start by crushing dried Cotinus coggygria.

Perform reflux extraction with 80% ethanol at 85°C for 2 hours, repeating the process thrice.

Filter the extraction solution to separate the residue from the filtrate.

Recover ethanol from the residue for reuse.

Concentrate the filtrate under vacuum until its specific gravity reaches 1.1 to 1.15.

Crystallize the concentrated extract using ethanol.

Filter and dry the crystallized product.

Crush and screen the dried material.

Inspect the final product before packaging.

Fisetin Powerful Benefits :

1. Senolytic Activity (Anti-Aging)

Fisetin helps remove senescent cells (damaged cells that promote aging and inflammation).

Considered one of the most potent natural senolytics (alongside quercetin and dasatinib).

2. Neuroprotection

Reduces oxidative stress in neurons.

It may protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Supports memory and cognitive function in animal models.

3. Anti-Inflammatory

Suppresses inflammatory cytokines (like IL-6 and TNF-α).

It may be beneficial for conditions like arthritis or metabolic syndrome.

4. Antioxidant

Scavenges free radicals.

Protects cells from oxidative damage that contributes to chronic diseases and aging.

5. Anticancer Potential

Promotes apoptosis (cell death) in tumor cells.

Modulates cell signaling pathways (e.g., PI3K/Akt, NF-κB).

6. Cardiovascular Health

It may help reduce LDL oxidation and improve endothelial function.

Animal studies show lowered blood pressure and better vascular health.

Bulk Fisetin Powder Specifications

Fisetin 50%

Fisetin 98%

Lipidosome fisetin

Fisetin Safe Dosage

The safe dosage of fisetin as a dietary supplement can vary depending on the intended use (e.g., general health, anti-aging, improved cognition), body weight, and individual health conditions.

For general antioxidant or anti-inflammatory support:

100–500 mg/day (commonly used in dietary supplements)

For senolytic effects (clearing senescent cells):

High-dose short-term protocols have been studied: 20 mg/kg/day for 2 consecutive days per month

(used in Mayo Clinic-backed study; equals about 1,400 mg/day for a 70 kg adult)

Applications

• Dietary Supplements: Capsules, tablets, softgels, or gummies

• Functional Beverages & Nutraceuticals

• Anti-Aging Formulas & Brain Health Products

• Cosmetics & Skincare Products

• Pharmaceutical and Research Applications

Where to buy the best wholesale Fisetin powder?

If you’re looking for a high-quality Fisetin supplier or manufacturer, Nutraflux is an excellent choice.

Reliable Manufacturing: Nutraflux specializes in the production of plant-derived active ingredients, including fisetin extracted from Cotinus coggygria, ensuring consistent quality and high purity.

Strict Quality Control: Every batch undergoes comprehensive testing, including HPLC purity analysis, heavy metal screening, and microbial checks, to meet international standards.

Private Label & Bulk Supply: Whether you need fisetin in bulk or customized formulas for private label supplements, Nutraflux offers flexible and scalable solutions.

Global Export Experience: With years of experience exporting to North America, Europe, and Asia, Nutraflux understands the regulatory and documentation needs of international clients.

Stable Inventory & Timely Delivery: Backed by strong production capabilities and efficient logistics, Nutraflux ensures on-time delivery and stable supply throughout the year.

B2B Procurement & Partnership

Nutraflux works closely with global brands, contract manufacturers, and health supplement developers. Whether you need bulk Fisetin powder, formulation advice, or customized solutions, we provide end-to-end support to ensure your products succeed in the market.